| Date | Location | Result | |
| 02/26/22 | Campus Center Gym | Jefferson 68, Holy Family 59 | Box score |
| 02/23/22 | Campus Center Gym | Goldey-Beacom 80, Holy Family 78 (OT) | Box score |
| 02/19/22 | Philadelphia, PA | USciences 73, Holy Family 68 | Box score |
| 02/12/22 | Campus Center Gym | Holy Family 61, Nyack 53 | Box score |
| 02/09/22 | Wellness Center/Lakewood, N.J. | Holy Family 62, Georgian Court 53 | Box score |
| 02/01/22 | Campus Center Gymnasium | Wilmington (Del.) 70, Holy Family 60 | Box score |
| 01/30/22 | Job Gymnasium/Rutherford, N.J. | Felician 99, Holy Family 73 | Box score |
| 01/26/22 | Sorgenti Arena | Chestnut Hill 63, Holy Family 59 | Box score |
| 01/23/22 | Campus Center Gym | Dominican (N.Y.) 69, Holy Family 52 | Box score |
| 01/18/22 | Philadelphia, PA | Jefferson 71, Holy Family 66 | Box score |
| 01/15/22 | Campus Center Gym | Holy Family 75, Bloomfield 68 | Box score |
| 01/11/22 | Wilmington, DE | Goldey-Beacom 75, Holy Family 61 | Box score |
| 01/08/22 | Caldwell, N.J.-Corino Court | Caldwell 61, Holy Family 55 | Box score |
| 01/05/22 | Campus Center Gym | Holy Family 55, USciences 45 | Box score |
| 01/02/22 | Waterbury, Conn. | Post 93, Holy Family 55 | Box score |
| 12/30/21 | Campus Center Gym | Holy Family 99, Dist. Columbia 68 | Box score |
| 12/19/21 | New Haven, CT | Holy Family 87, Southern Conn. St. 62 | Box score |
| 12/16/21 | Campus Center Gym | Holy Family 90, Cheyney 64 | Box score |
| 12/12/21 | Aquinas Hall Gym - Sparkill, NY | St. Thomas Aquinas 90, Holy Family 68 | Box score |
| 12/07/21 | Campus Center Gym | Georgian Court 50, Holy Family 47 | Box score |
| 12/04/21 | Newark, DE | Wilmington (DE) 80, Holy Family 71 | Box score |
| 12/01/21 | Philadelphia, PA | Chestnut Hill 67, Holy Family 58 | Box score |
| 11/28/21 | Campus Center Gym | West Chester 74, Holy Family 69 | Box score |
| 11/23/21 | Campus Center Gym | Lock Haven 67, Holy Family 64 | Box score |
| 11/20/21 | Campus Center Gym | Holy Family 73, Queens (N.Y.) 65 (2OT) | Box score |
| 11/17/21 | Lincoln Univ., PA - Manuel Rivero Gym | Lincoln (PA) 77, Holy Family 58 | Box score |
| 11/14/21 | Philadelphia, PA | American Int'l 66, Holy Family 64 | Box score |
| 11/13/21 | Philadelphia, PA | Holy Family 91, Franklin Pierce 84 | Box score |